Jose McFaline

Postdoctoral Fellow
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I am a post-doctoral fellow in the Trapnell lab. I received my B.S. in Chemistry at the University of Puerto Rico at Mayag├╝ez. I then went on to complete my Ph.D. in Biology at MIT with a focus on Cancer Systems Biology in the laboratories of Professor Leona Samson and Professor Forest White. As a member of the Samson and White labs I worked on identifying mechanisms of chemoresistance in glioblastoma, the most common and malignant brain cancer. Using a variety of molecular biology and proteomic approaches I identified alterations in DNA repair and mitogenic signaling networks that modulate the response of glioblastoma cells to the main chemotherapeutic used in the treatment of the disease, temozolomide.


On the design of CRISPR-based single-cell molecular screens

Chromatin accessibility dynamics of myogenesis at single cell resolution